Hypertrophic pulmonary osteoarthropathy with esophageal sarcomatoid carcinoma: a case report

Hypertrophic pulmonary osteoarthropathy (HPOA), mainly manifested clubbing, is rare in patients with esophageal sarcomatoid carcinoma. We herein describe a 48-year-old Chinese man whose advanced carcinoma was diagnosed while examining his symptoms of HPOA. The patient had no opportunity surgery after surgical evaluation. Chemoradiation, including 5 cycles chemotherapy (Paclitaxel liposome 60 mg day 1 and nedaplatin 30 1, q1w) 6MV-X/VMAT-95%PGTV 59.92 Gy/2.14 Gy/28 F 95%PTV 50.4 Gy/1.8 F, subsequent 6 (paclitaxel 210 50 2, q3w) shrank the tumor condition became stable without clubbing remission or exacerbation. No medical case report found PubMed search indexed English-language literature past 20 years, though there are some reports HPOA combined other pathologic types patient's effectively controlled by radiotherapy showed disease. However, five-year survival rate very low life quality, adverse reactions also contribute to quality. purpose this present feature our treatment for primary HPOA, which could be helpful further understanding disease clinical decision making. Moreover, article reviews esophagus. look forward breakthrough immunotherapy molecular targeting therapy improve situation.